RIBOSOME BIOGENESIS DISRUPTION MEDIATED CHROMATIN STRUCTURE CHANGES REVEALED BY SRATAC, A CUSTOMIZABLE END TO END ANALYSIS PIPELINE FOR ATAC-SEQ

Abstract The nucleolus is a large nuclear body that serves as the primary site for ribosome biogenesis.Recent studies have suggested that it also plays an important role in organizing chromatin architecture.However, to establish a causal relationship between nucleolar ribosome assembly oolution light up and chromatin architecture, genetic tools are

This work presents one and two-dimensional numerical analyses using isotropic and anisotropic damage models for the concrete in order to discuss the advantages of these modeling.Initially, it is shortly described the damage model proposed by Mazars.This constitutive model assumes the concrete lpc330v as isotropic and elastic material, where locally